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COMPANY OVERVIEW
PAX Therapeutics is a US-based company dedicated to optimize healing of tendon and ligament injuries to restore full mobility and improved function faster than current approaches.
Spun out of the labs at Rhode Island Hospital (a major teaching affiliate of The Warren Alpert Medical School of Brown University) of Dr. Paul Liu, a Harvard Medical School-trained surgeon-scientist, PAX Therapeutics provides a unique approach that capitalizes on the advances in gene delivery that have made vectors a safe technology for regenerative medicine, vaccines, and use in infants/children. PAX-001 provides a biological mechanism to optimize healing besides the surgical intervention, because it results in the desired Type 1 collagen to be produced from the start, rather than scar (Type 3) collagen).
Research over 15 years performed in the founder’s academic lab led to the specific combination of vector and growth factor gene and mechanism of healing for use for both tendons and ligaments and for human (and eventually veterinary) applications.
VALUES
THE FUTURE OF OPTIMIZED TENDON AND LIGAMENT REPAIR IS HERE
VISION:
To optimize the treatment of tendon and ligament injuries in both humans and animals
MISSION:
Our mission is to focus on patients by bringing the dedication and skill of our team to enable an innovative therapy to optimize tendon and ligament healing to decrease the disability, suffering, and economic burden for patients, payers, and suppliers.
CORE VALUES:
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Scientific Innovation: To never accept current approaches and outcomes as acceptable, particularly when inequities exist that can be addressed by creative careful science.
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Integrity: To adhere to the highest standards and professionalism for ethics and responsibility to the patients.
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Value: To increase value for patients by improving outcomes and knowing that by putting the patient first, the company will do well. Efforts focus on demonstrating the benefit of PAX's approach as efficiently as possible to bring this breakthrough to patients and value to investors, as soon as possible.
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Excellence: To deliver the highest quality service and products to our investors and patients through exceptional leadership and a focused, dedicated and insightful team.
LEADERSHIP
Executive Leadership
Margaret A. Liu, MD, DSchc, MDhc, FISV
CEO
Co-Founder and CSO
CFO and VP, Operations and Business
Chief Business Development Officer
Surgical Advisory Board
Plastic Surgery
Orthopedic Surgery
Plastic Surgery
Development and Regulatory Advisors
Regulatory Affairs
Surgical Advisor
Tendon Repair Expertise
Margaret A. Liu, MD, DSchc, MDhc, CEO
Margaret is a Harvard Medical School graduate and a world-renowned expert in the fields of gene delivery, vaccines and immunotherapy. She has been a Director, then Advisory Council member, of the American Society for Gene and Cell Therapy, Vice-President of Vaccines and Gene Therapy at Chiron, Senior Advisor for the Bill & Melinda Gates Foundation, and board member at Transgene, Sangamo, Ipsen, and MacroGenics, among other executive, board, and SAB positions. Margaret is Hedersdoktor (Honorary Doctor) with Scientific Affiliation at the Karolinska Institutet in Stockholm, and Adjunct Full Professor at the University of California, San Francisco.
Xiao Tian Wang, MD, Co-founder & Chief Scientific Officer
Xiao is a Research Assistant Professor at Brown University and has been involved in gene therapy research with Dr. Paul Liu for 20 years. She developed the AAV2-VEGF vector, and the work (this project) won the 3M Award of Excellence in Translational Regenerative Science at a Wound Healing Society Annual Meeting.
Sanjay Gokhale, MBA, VP of Corporate Development & CFO
Sanjay has more than three decades of experience in Investment Banking, Venture Capital, Corporate Development and Entrepreneurship. He has been involved in M&A advisory assignments, as well as financing and licensing transactions valued in excess of $10 billion. Sanjay holds a Bachelor of Chemical Engineering degree from the Institute of Chemical Technology in India, and an MBA from Rice University in Houston, Texas.
Robert G. Johnson, MD, PhD, Chief Business Development Officer
Robert received his MD and PhD from UPenn, and has served on the medical faculties of Harvard Medical School and UPenn as a Howard Hughes Medical Institute Investigator. He was CEO of KOSAN Pharmaceuticals, and COO for GenVivo, Inc. developing gene therapy cancer therapeutics and managing their research, clinical trials, manufacturing, and intellectual property.
Karl H. Breuing, MD, FACS, Surgical Clinical Advisor
Karl is Professor of Surgery at The Warren Alpert Medical School of Brown University and a board-certified plastic and reconstructive surgeon with internationally recognized expertise in regenerative medicine, wound healing, and reconstructive surgery. Over a distinguished career spanning more than four decades, he has advanced the clinical application of biomaterials and tissue regeneration while serving as an educator, researcher, and advisor to the medical device and biotechnology industries.
Manuel F. DaSilva, MD, FAAOS, Surgical Clinical Advisor
Manuel is a Professor of Orthopedics at the Warren Alpert Medical School of Brown University. He specializes in the treatment of injuries and musculoskeletal conditions related to the hand, wrist, elbow, and shoulder having completed advanced training in orthopedic trauma, and hand, wrist, elbow, shoulder, and micro-vascular surgery. He has pioneered elbow arthroscopy techniques for the treatment of elbow pathologies, as well as arthroscopic techniques for the small joints of the hand and wrist. He in an inventor and innovator holding multiple patents related to surgical instrumentation.
Joseph C. Benacci, MD, FACS, Surgical Clinical Advisor
Joe is a graduate of the University of Pennsylvania School of Medicine. He trained in General Surgery at the Mayo Clinic in Minnesota, did his Plastic Surgery at the Lahey Clinic in Massachusetts and did a Reconstructive Microsurgery Fellowship at the MD Anderson Cancer Center in Texas. Joe is a Plastic Surgeon at the Emplify - Gundersen Health System in Wisconsin where he formerly served as Chairman in Plastic Surgery for 16 years.
Richard Junghans, MD, PhD, Advisor for Clinical Trials
Dick earned his PhD in Immunology from UC Berkeley, followed by a Post-doc at CalTech, then attended medical school at U Miami. He has patented and developed armed targeted T-cell therapies for several cancers, and has completed multiple gene therapy clinical trials that afford him unique insight into FDA requirements and reporting. He is a practicing oncologist and President of IT BIO, LLC.
Jin Bo Tang, MD, Surgical Advisor for Tendons and Ligaments
Dr. Jin Bo Tang is Secretary-General of International Federation for Societies of Surgery of the Hand (IFSSH) and will be president 2031-2034. He is Editor-in-Chief of the acclaimed new hand surgery text book Current Practice in Hand Surgery, published by Elsevier in 2025. This is the first comprehensive textbook supported by IFSSH for the worldwide hand surgery community.
In memoriam Paul Liu, MD, MA, MA ad eundem, Co-Founder
Paul was Chair and Professor of Plastic Surgery at Brown University. He was educated at Harvard Medical School and Oxford University, where he was a Marshall Scholar. Paul was trained in general surgery and plastics at the Brigham / Children’s / Harvard. He is Past President of the Wound Healing Society, and led a clinical department of 10 surgeons and 40 employees with revenues of ~$25 million/year.